All components are built with outstanding precision, ensuring uninterrupted operation at minimal maintenance costs.

Process vessels

We build stainless steel process vessels and are experts in working with special alloys, for example hastelloy and incoloy. Our solutions for building process vessels include: 

  • a special in-line dosing system,
  • flexible connections of reactor and mixing vessels to the pipe systems or other reactor vessels,
  • use of organic solvents or only water,
  • mobile vessels, 
  • integrated stirrers depending on the client’s requirements, 
  • possible connection to a central CIP and DIP module,
  • possible connection to a cooling/heating unit,
  • mechanical finish of all contact and sealing surfaces, sealing without blind spots,
  • the use of retractable washing heads for cleaning in place,
  • the automated dosing of ingredients and control weighing.

Our solutions comply with customer requirements and provide flexible production.

Containers (IBC)

Brinox has developed containers (IBC) of different shapes, sizes (20–3500 L) and gripper systems for batch production. Robotic welding and grinding ensure extraordinary dimensional stability of the containers and excellent welds.

Our added value is the professional special chemical cleaning procedure that includes the removal of all impurities and passivation of stainless surfaces after welding and grinding.

The inlet and outlet holes are made in line with the client’s requirements.

Our competitive advantage is the adaptation to the client’s existing systems already owned by potential partners, and help with the standardisation of MHS systems.

Docking stations

The Brinox docking stations were developed in close cooperation between the experts from Brinox and clients from the pharmaceutical industry.


  • Automated using a SCADA system,
  • long service life,
  • SMEPAC certificate,
  • built in line with GMP requirements,
  • allow for safe operation and management (OEB 3 certificate),
  • easy to maintain and clean, with a lower cleaning medium consumption,
  • active cooling – after cleaning they are ready for use in 30 minutes (optional),
  • deaeration valve preventing vacuum (optional),
  • the innovative Brinox washing nozzle ensures efficient washing and drying.
Flap valve

With the Brinox flap valves we reach an OEB 1–2, and in case of an additional local extraction by suction an OEB 3.

The drive can be manual, pneumatic or a combination of both. We build different solutions as requested by the clients.

We produce two types of valves (DN 100, 150, 200, 250, 300):

  • with soft flaps for MHS systems for tablets, capsules
  • with stainless flaps for MHS system for granulates, powders
Conical valve

With Brinox conical valves the OEB 3 is reached.

The most used conical valve is the DN 400 mm, used especially in cases of poorly flowing powder materials.

The conical valve is installed in the IBC.

At the installation site the receiving unit is connected to the process device or receiving container.

The system of conical valves produced by Brinox is used for:

  • multilevel gravity transfer of powder materials, tablets and capsules,
  • single-level gravity system.
Tube heat exchangers

We design and build hygiene tube heat exchangers in line with the cGMP, ATEX and PED directives.

The special double-flanged construction ensures that no mixing of the heating or cooling medium with the pharmaceutical liquid can occur; this prevents contaminations.

Granulation, drying and coating

The drying, granulation and coating systems allows:

  • batch sizes from 10 to 600 L, 
  • the execution of all three operations with a single system, 
  • a homogeneous distribution of particles, 
  • influencing the coating quality, 
  • a shorter process time, 
  • fully automated operation supervision functions, 
  • automated washing of the system (CIP),
  • explosion safety (due to the innovative seal the system can withstand pressures up to 12 bar),
  • leakage-proof operation during the process decreases the operator’s exposure.

The system is made from AISI316L stainless steel and equipped with standard measuring instruments and other automation components.  


The formulations of solid products are always connected with the selection and mixing of various substances and the active ingredient. The size, form and other characteristics of powder particles are crucial for the mixing (blending) process.

Using the Brinox mixers and containers (IBC) we achieve results that comply with clients’ requirements.

We assure:

  • the safe addition of additives to ensure the prescribed OEB and explosion safety (with Brinox MHS systems),
  • IBCs from our own production that allow us to adapt to the client’s requirements and introduce the required blending,
  • the production of mixers adapted to the client's requirements
Retractable washing head

In all CIP application with low-pressure washing we can see that the retractable washing head is a great advantage due to its unique construction that allows:

  • to align the vessel body or connecting pipe with the retractable head front,
  • a very good distribution of the jet to the rotating manifold,
  • good wetting results (wetting angle 220–180°),
  • the retractable head is self-cleaning and used in pairs,
  • retractable heads are used also to distribute hot compressed air or nitrogen for drying.
Storage and distribution of detergents

A good solution for the pharmaceutical industry with several CIP modules and washing systems is the central storage and distribution of detergents.

Brinox provides an efficient system for precisely dosing detergents to washing systems in accordance with recipes, to monitor consumption by working order or cost centres, and easy logistics.


The detergent storage and distribution system is built in such a way as to provide the distribution installations for each CIP module or washing system.


The required dosing uses separate volume dosing pumps.
Storage systems can use standard containers or the detergents can be stored in separate vessels.

Fresenius Kabi
Johnson & Johnson
Leo Pharma
Aerie Pharmaceuticals
CSL Behring
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